[Expression of receptor activator of nuclear factor-κB ligand in keratocystic odontogenic tumor before and after decompression].

PURPOSE: To investigate the expression of receptor activator of nuclear factor-κB ligand (RANKL) in keratocystic odontogenic tumor (KCOT) before and after decompression. METHODS: Twenty two pairs of paraffin-embeded tissue specimens of KCOT were collected and subjected to immunohistochemical analysis of RANKL.The data were analyzed with SPSS17.0 software package for paired t test. RESULTS: RANKL positive cells were observed in the preoperative KCOT epithelium. The expression of RANKL was down-regulated after decompression(P<0.05). CONCLUSIONS: Decrease of RANKL expression after decompression may facilitate the lining epithelium of KCOT transforming to normal oral mucosal epithelium.

[Salivary duct carcinoma: report of 6 cases and review of the literature].

PURPOSE: To summarize the clinicopathologic characteristics, treatment and prognosis of salivary duct carcinoma. METHODS: Six cases of salivary duct carcinoma treated in our hospital were reported. And the literatures were reviewed. All cases were proved by operation and pathology. The clinical characteristics, histological features, therapeutic method and prognosis were analyzed. RESULTS: Salivary duct carcinoma predominantly influenced old male patients and mainly occurred in the parotid gland. Physical examination revealed a firm, immobile and poorly defined mass accompanied by nerve infiltrated symptom. The histological appearance was characterized by solid cell nests with ductal structures and central comedonecrosis. Treatment required extensive resection and radical neck dissection with postoperative radiotherapy. The clinical course was marked by development of both local disease recurrence as well as cervical lymph node and distant metastasis. CONCLUSIONS: Salivary duct carcinoma is a rare malignant salivary tumour with poor prognosis. Extensive resection is the key to improve the survival rate.

[Bisphosphonate related osteonecrosis of the jaws: a case report and review of the literature].

Bisphosphonate compounds are used to treat osteoporosis and malignant bone metastasis. Despite the benefits related to use of these medications, osteonecrosis of the jaws is a significant complication in a subset of patients receiving these drugs. This complication occurs either spontaneously or after a simple dento-alveolar surgery. Recently there was a patient who showed the features of bisphosphonate related osteonecrosis of the jaws (BRONJ) in our hospital. This article reported one typical case of osteonecrosis of the maxilla treated with Zoledronic acid and reviewed the relevant literature related to pathogenesis, clinical presentation as well as management and prevention of this new complication.

[Spindle cell squamous carcinoma of the oral cavity: report of 2 cases].

Two cases with spindle cell squamous carcinoma were reported in this paper. The clinical, histopathologic features, therapy and prognosis were discussed. These tumors probably represented a heterogeneous group of squamous cell carcinoma whose components required either an identifiable squamous cell carcinoma or evidence of epithelial differentiation in the spindle cell. The clinical features were as follow: presents a male predominance among 60 to 70 years and site predilection for the low lip, tongue and gingiva, more aggressive and easy lymphatic metastases. Wide surgical excision, alone or with radical neck dissection was the most successful therapeutic modality. Local recurrence, lymphatic metastases and the depth of tumor invasion into underlying structures were found to be reliable prognostic indicators, the prognosis was dismal.